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Optimization

VIVEbiotech has dedicated Process Development Upstream (USP) and Process Development Downstream (DSP) departments focused on process optimization, aiming to deliver efficient, scalable and compliant production of functional, cost-effective vectors for both ex-vivo and in-vivo administration.
Importantly, VIVEbiotech´s manufacturing platform is the same for Developmental Engineering and GMP batches.
The Upstream Development Department is in charge of:
  • Adjusting the initial seed-train expansion process.
  • Defining optimal seeding conditions for bioreactors.
  • Selecting the best conditions for transfection.
  • Defining the optimal conditions for harvesting.
  • Determining in-process controls (IPCs).
  • Testing new technologies with the constant objective of enhancing productivity during USP.

The Downstream Development Department is in charge of:

  • Optimizing chromatographic process performance.
  • Adjusting tangential flow filtration (TFF).
  • Developing the best approach to Fill & Finish (F&F) operations.
  • Determining in-process controls (IPCs).
  • Testing new technologies with the constant objective of enhancing productivity during DSP.
Once our development and optimization strategy has been completed, our ultimate goal is to transfer these improvements to benefit the services provided to our customers.