Our science
Lentiviral Vectors: From Wild-Type Viruses to Efficient Multi-Functional Delivery Vectors
Review
International Journal of Molecular Sciences
2025
A. Arrasate, C. López-Robles, M. Zuazo, S. Baños-Mateos, C. Martín, A. Lamsfus-Calle, M.J. Fertin
© The authors, 2025. Licensed under Creative Commons Attribution 4.0 (CC BY 4.0). Source: International Journal of Molecular Sciences.
Abolishing Retro-Transduction of Producer Cells in Lentiviral Vector Manufacturing
Article
Viruses
2024
S. Banos-Mateos, C. Lopez-Robles, M.E. Yubero, A. Jurado, A. Arbelaiz-Sarasola, A. Lamsfus-Calle, A. Arrasate, C. Albo, J.C. Ramírez, M.J. Fertin
© The authors, 2024. Licensed under Creative Commons Attribution 4.0 (CC BY 4.0). Source: Viruses.
Establishment and Characterization of a Stable Producer Cell Line Generation Platform for the Manufacturing of Clinical-Grade Lentiviral Vectors
Article
Biomedicines
2024
A. Arrasate, I. Bravo, C. Lopez-Robles, A. Arbelaiz-Sarasola, M. Ugalde, M.L. Meijueiro, M. Zuazo, A. Valero, S. Banos-Mateos, J.C. Ramirez, C. Albo, A. Lamsfus-Calle, M.J. Fertin
© The authors, 2024. Licensed under Creative Commons Attribution 4.0 (CC BY 4.0). Source: Biomedicines.
CS1 CAR-T targeting the distal domain of CS1 (SLAMF7) shows efficacy in high tumor burden myeloma model despite fratricide of CD8+CS1 expressing CAR-T cells
Article
Leukemia
2022
J. O’Neal, J.K. Ritchey, M.L. Cooper, J. Niswonger, L.S. González, E. Street, M.P. Rettig, S.W. Gladney, L. Gehrs, R. Abboud, J.L. Prior, G.J. Haas, R.G. Jayasinghe, L. Ding, A. Ghobadi, R. Vij, J.F. DiPersio
© The authors, 2022. Licensed under Creative Commons Attribution 4.0 (CC BY 4.0). Source: Leukemia.
Scalable Cell Detachment Process Enabling Direct Seeding of Large-Scale 200 m2 and 600 m2 Bioreactors
ISCT Annual Meeting
Dublin
2026
M. Echeverria, C. Salgado, H. Fernandez, C. Amagliani, M.J. Fertin
Establishment and characterization of a stable producer cell line generation platform for the manufacturing of clinical-grade lentiviral vectors
Bioprocessing Summit Europe
Barcelona
2025
A. Arrasate, I. Bravo, C. Lopez, A. Arbelaiz, M. Ugalde, M.L. Meijueiro, M. Zuazo, A. Valero, S. Baños, J.C. Ramirez, C. Albo, A. Lamsfus, M.J. Fertin
Design and validation of a GMP compliant stem cell manufacturing protocol for gene therapy in Deficiency of adenosine deaminase 2 (DADA2)
ESGCT Annual Congress
Seville
2025
Y. Hong, Y. Bian, K.F. Buckland, E. Morgan, R. Nguyen, S. Fibrrahim, K. Orf, A.J. Thrasher, E. Morris, P.A. Brogan, D. Eleftheriou
Presented by UCL
Lentiviral vector manufacture ad-hoc optimization and development strategies to overcome cell-therapy cost-effectiveness and regulatory hurdles: a real-life example
ESGCT Annual Congress
Rome
2024
M. Zuazo, M.Ugalde, M.Orbegozo,
M. Zubizarreta, L.Razquin,
S.Lameynardie, E. Rutjens, M, Fertin
In collaboration with Advesya
Establishment and characterization of a stable producer cell line generation platform for the manufacturing of clinical-grade lentiviral vectors
ESGCT Annual Congress
Rome
2024
A. Arrasate, I. Bravo, C. Lopez, A. Arbelaiz, M. Ugalde, M.L. Meijueiro, M. Zuazo, A. Valero, S. Baños, J.C. Ramirez, C. Albo, A. Lamsfus, M.J. Fertin
Lentiviral CAR-T backbone promotor configuration determine vector production yield and vector functionality by modulating viral genome production and packaging yields
ESGCT Annual Congress
Brussels
2023
M. Zuazo, A. Lamsfus, M.Ugalde, M.L. Meijueiro, A. Arrasate I. Bravo, M.J. Fertin
Abolishing retro-transduction of producer cells in lentiviral vector manufacturing
ESGCT Annual Congress
Brussels
2023
S. Banos-Mateos, C. Lopez-Robles, M. E. Yubero, A. Jurado, A. Arbelaiz, M.J. Fertin.
INTRONPLUS-PKRknock-out in viral producer cell lines enables stable lentiviral vector integrity
ESGCT Annual Congress
Edinburgh
2022
M.L. Meijueiro, I. Bravo, A. Arrasate, C. Lopez-Robles, S. Baños-Mateos, M.J. Fertín, C. Albo, A. Lamsfus-Calle
Pushing the right buttons: genetic silencing in producing cell lines to boost lentiviral vector production led to metabolic disfunction counteracting vector requirements
ESGCT Annual Congress
2021
C. Lopez, M.E. Yubero, A. Arbelaiz, J.C. Ramirez, C. Albo